Bridge the Gap – SYNGAP – Education and Research Foundation

2016

 

Expansion of the RASopathies.

Tidyman WE, Rauen KA. Curr Genet Med Rep. 2016 Sep;4(3):57-64. Epub 2016 Jul 1.

 

Correction: A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain ‘Slots’ in the postsynaptic density.

Walkup WG, Mastro TL, Schenker LT, Vielmetter J, Hu R, Iancu A, Reghunathan M, Bannon BD, Kennedy MB.  Elife. 2016 Oct 19;5. pii: e22495. doi: 10.7554/eLife.22495. No abstract available.

 

A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain ‘Slots’ in the postsynaptic density.

Walkup WG, Mastro TL, Schenker LT, Vielmetter J, Hu R, Iancu A, Reghunathan M, Bannon BD, Kennedy MB.  Elife. 2016 Sep 13;5. pii: e16813. doi: 10.7554/eLife.16813. Erratum in: Elife. 2016 Oct 19;5:.

 

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.

Zeng M, Shang Y, Araki Y, Guo T, Huganir RL, Zhang M.  Cell. 2016 Aug 25;166(5):1163-1175.e12. doi: 10.1016/j.cell.2016.07.008.

 

CaMKII-mediated displacement of AIDA-1 out of the postsynaptic density core.

Dosemeci A, Toy D, Burch A, Bayer KU, Tao-Cheng JH.  FEBS Lett. 2016 Sep;590(17):2934-9. doi: 10.1002/1873-3468.12334. Epub 2016 Aug 20.

 

Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders.

Xing J, Kimura H, Wang C, Ishizuka K, Kushima I, Arioka Y, Yoshimi A, Nakamura Y, Shiino T, Oya-Ito T, Takasaki Y, Uno Y, Okada T, Iidaka T, Aleksic B, Mori D, Ozaki N.  Sci Rep. 2016 Jun 7;6:27491. doi: 10.1038/srep27491.

 

New partners and phosphorylation sites of focal adhesion kinase identified by mass spectrometry.

Masdeu Mdel M, Armendáriz BG, Soriano E, Ureña JM, Burgaya F.  Biochim Biophys Acta. 2016 Jul;1860(7):1388-94. doi: 10.1016/j.bbagen.2016.02.019. Epub 2016 Mar 28.

 

SYNGAP1: Mind the Gap. 

Jeyabalan N, Clement JP.  Front Cell Neurosci. 2016 Feb 15;10:32. doi: 10.3389/fncel.2016.00032. eCollection 2016 Feb 15. Review.

 

Proteomic analysis of PSD-93 knockout mice following the induction of ischemic cerebral injury.

Rong R, Yang H, Rong L, Wei X, Li Q, Liu X, Gao H, Xu Y, Zhang Q.  Neurotoxicology. 2016 Mar;53:1-11. doi: 10.1016/j.neuro.2015.12.005. Epub 2015 Dec 8.

 

2015

 

RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells.

Tam SY, Lilla JN, Chen CC, Kalesnikoff J, Tsai M.  PLoS One. 2015 Nov 20;10(11):e0142935. doi: 10.1371/journal.pone.0142935. eCollection 2015 Nov 20.

 

Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice. 

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ.  J Neurosci. 2015 Nov 11;35(45):15073-81. doi: 10.1523/JNEUROSCI.1087-15.2015.

 

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies.

Giovanoli S, Weber-Stadlbauer U, Schedlowski M, Meyer U, Engler H.

Brain Behav Immun. 2016 Jul;55:25-38. doi: 10.1016/j.bbi.2015.09.015. Epub 2015 Sep 25.

 

AIDA-1 Moves out of the Postsynaptic Density Core under Excitatory Conditions.

Dosemeci A, Toy D, Reese TS, Tao-Cheng JH.  PLoS One. 2015 Sep 10;10(9):e0137216. doi: 10.1371/journal.pone.0137216. eCollection 2015 Sep 10.

 

Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers.

Codocedo JF, Montecinos-Oliva C, Inestrosa NC.  Front Cell Neurosci. 2015 Jun 15;9:227. doi: 10.3389/fncel.2015.00227. eCollection 2015 Jun 15.

 

De novo, heterozygous, loss-of-function mutations in SYNGAP1 cause a syndromic form of intellectual disability. 

Parker MJ, Fryer AE, Shears DJ, Lachlan KL, McKee SA, Magee AC, Mohammed S, Vasudevan PC, Park SM, Benoit V, Lederer D, Maystadt I, Study D, FitzPatrick DR.  Am J Med Genet A. 2015 Oct;167A(10):2231-7. doi: 10.1002/ajmg.a.37189. Epub 2015 Jun 15.

 

The Ras GTPase-activating protein Rasal3 supports survival of naive T cells.

Muro R, Nitta T, Okada T, Ideta H, Tsubata T, Suzuki H.  PLoS One. 2015 Mar 20;10(3):e0119898. doi: 10.1371/ journal.pone.0119898. eCollection 2015 Mar 20.

 

Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP.

Araki Y, Zeng M, Zhang M, Huganir RL.  Neuron. 2015 Jan 7;85(1):173-89. doi: 10.1016/j.neuron.2014.12.023.

 

Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.

Walkup WG 4th, Washburn L, Sweredoski MJ, Carlisle HJ, Graham RL, Hess S, Kennedy MB.  J Biol Chem. 2015 Feb 20;290(8):4908-27. doi: 10.1074/jbc.M114.614420. Epub 2014 Dec 22.

 

2014

 

Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway. 

Huo XL, Min JJ, Pan CY, Zhao CC, Pan LL, Gui FF, Jin L, Wang XT.  PLoS One. 2014 Apr 9;9(4):e94278. doi: 10.1371/journal.pone.0094278. eCollection 2014 Apr 9.

 

PDZ affinity chromatography: a general method for affinity purification of proteins based on PDZ domains and their ligands.

Walkup WG 4th, Kennedy MB.  Protein Expr Purif. 2014 Jun;98:46-62. doi: 10.1016/j.pep.2014.02.015. Epub 2014 Mar 6.

 

SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.

Wang CC, Held RG, Hall BJ.  PLoS One. 2013 Dec 31;8(12):e83941. doi: 10.1371/journal.pone.0083941. eCollection 2013 Dec 31.

 

2013

 

Camkii-mediated phosphorylation regulates distributions of Syngap-α1 and -α2 at the postsynaptic density.

Yang Y, Tao-Cheng JH, Bayer KU, Reese TS, Dosemeci A.  PLoS One. 2013 Aug 13;8(8):e71795. doi: 10.1371/journal.pone.0071795. eCollection 2013 Aug 13.

 

The MEF2 family and the brain: from molecules to memory.

Dietrich JB.  Cell Tissue Res. 2013 May;352(2):179-90. doi: 10.1007/s00441-013-1565-2. Epub 2013 Feb 9. Review.

 

Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses.

Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, Xu X, Rumbaugh G.

Cell. 2012 Nov 9;151(4):709-23. doi: 10.1016/j.cell.2012.08.045.

 

SynGAP isoforms exert opposing effects on synaptic strength.

McMahon AC, Barnett MW, O’Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC.

Nat Commun. 2012 Jun 12;3:900. doi: 10.1038/ncomms1900.

 

Experience-dependent regulation of functional maps and synaptic protein expression in the cat visual cortex.

Jaffer S, Vorobyov V, Kind PC, Sengpiel F.  Eur J Neurosci. 2012 Apr;35(8):1281-94. doi: 10.1111/j.1460-9568.2012.08044.x.

 

Arsenite exposure altered the expression of NMDA receptor and postsynaptic signaling proteins in rat hippocampus.

Luo JH, Qiu ZQ, Zhang L, Shu WQ.  Toxicol Lett. 2012 May 20;211(1):39-44. doi: 10.1016/j.toxlet.2012.02.021. Epub 2012 Mar 8.

 

2011

 

SynGAP moves out of the core of the postsynaptic density upon depolarization.

Yang Y, Tao-Cheng JH, Reese TS, Dosemeci A.  Neuroscience. 2011 Sep 29;192:132-9. doi: 10.1016/j.neuroscience.2011.06.061. Epub 2011 Jun 26. Erratum in: Neuroscience. 2012 Oct 25;223:487.

 

Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization.

Duarte DB, Duan JH, Nicol GD, Vasko MR, Hingtgen CM.  J Neurophysiol. 2011 Jul;106(1):309-18. doi: 10.1152/jn.00963.2010. Epub 2011 Apr 27.

 

Requirement for Plk2 in orchestrated ras and rap signaling, homeostatic structural plasticity, and memory.

Lee KJ, Lee Y, Rozeboom A, Lee JY, Udagawa N, Hoe HS, Pak DT.  Neuron. 2011 Mar 10;69(5):957-73. doi: 10.1016/j.neuron.2011.02.004.

 

2010

 

Microarray analysis of rat hippocampus exposed to excitotoxicity: reversal Na(+)/Ca(2+) exchanger NCX3 is overexpressed in glial cells.

Ortuño-Sahagún D, Rivera-Cervantes MC, Gudiño-Cabrera G, Junyent F, Verdaguer E, Auladell C, Pallàs M, Camins A, Beas-Zárate C.

Hippocampus. 2012 Feb;22(2):128-40. doi: 10.1002/hipo.20869. Epub 2010 Oct 6.

 

In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.

Delint-Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama NH, Grant SG.  J Neurosci. 2010 Jun 16;30(24):8162-70. doi: 10.1523/JNEUROSCI.1792-10.2010.

 

Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP.

Muhia M, Yee BK, Feldon J, Markopoulos F, Knuesel I.  Eur J Neurosci. 2010 Feb;31(3):529-43. doi: 10.1111/j.1460-9568.2010.07079.x. Epub 2010 Jan 25.

 

Regulation of phosphorylation at the postsynaptic density during different activity states of Ca2+/calmodulin-dependent protein kinase II.

Dosemeci A, Jaffe H.  Biochem Biophys Res Commun. 2010 Jan 1;391(1):78-84. doi: 10.1016/j.bbrc.2009.10.167. Epub 2009 Nov 5.

 

2009

 

Appetitively motivated instrumental learning in SynGAP heterozygous knockout mice. 

Muhia M, Feldon J, Knuesel I, Yee BK.  Behav Neurosci. 2009 Oct;123(5):1114-28. doi: 10.1037/a0017118.

 

SYNGAP: bridging the gap between genetic factors and autosomal non-syndromic mental retardation.

Huang K.  Clin Genet. 2009 Aug;76(2):149-51. doi: 10.1111/j.1399-0004.2009.01247_3.x. Epub 2009 Aug 7. No abstract available.

 

Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. 

Funk AJ, Rumbaugh G, Harotunian V, McCullumsmith RE, Meador-Woodruff JH.  Neuroreport. 2009 Jul 15;20(11):1019-22. doi: 10.1097/WNR.0b013e32832d30d9.

 

Crystal structure of the GTPase-activating protein-related domain from IQGAP1. 

Kurella VB, Richard JM, Parke CL, Lecour LF Jr, Bellamy HD, Worthylake DK.  J Biol Chem. 2009 May 29;284(22):14857-65. doi: 10.1074/jbc.M808974200. Epub 2009 Mar 25.

 

Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia. 

Guo X, Hamilton PJ, Reish NJ, Sweatt JD, Miller CA, Rumbaugh G.  Neuropsychopharmacology. 2009 Jun;34(7):1659-72. doi: 10.1038/npp.2008.223. Epub 2009 Jan 14.

 

2008

 

SynGAP regulates steady-state and activity-dependent phosphorylation of cofilin.

Carlisle HJ, Manzerra P, Marcora E, Kennedy MB.  J Neurosci. 2008 Dec 10;28(50):13673-83. doi: 10.1523/JNEUROSCI.4695-08.2008.

 

Differential distribution of synGAP alpha1 and synGAP beta isoforms in rat neurons.

Moon IS, Sakagami H, Nakayama J, Suzuki T.  Brain Res. 2008 Nov 19;1241:62-75. doi: 10.1016/j.brainres.2008.09.033. Epub 2008 Sep 19.

 

The MUPP1-SynGAPalpha protein complex does not mediate activity-induced LTP.

Rama S, Krapivinsky G, Clapham DE, Medina I.  Mol Cell Neurosci. 2008 Jun;38(2):183-8. doi: 10.1016/j.mcn.2008.02.007. Epub 2008 Mar 4.

 

Kalirin-7, a protein enriched in postsynaptic density, is involved in ischemic signal transduction.

Beresewicz M, Kowalczyk JE, Zabłocka B.  Neurochem Res. 2008 Sep;33(9):1789-94. doi: 10.1007/s11064-008-9631-y. Epub 2008 Mar 13.

 

The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction.

Pena V, Hothorn M, Eberth A, Kaschau N, Parret A, Gremer L, Bonneau F, Ahmadian MR, Scheffzek K.  EMBO Rep. 2008 Apr;9(4):350-5. doi: 10.1038/embor.2008.20. Epub 2008 Mar 7.

 

2007

 

UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3.

Avery AW, Figueroa C, Vojtek AB.  Cell Signal. 2007 Jan;19(1):177-84. Epub 2006 Aug 2.

 

2006

 

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons.

Rumbaugh G, Adams JP, Kim JH, Huganir RL.  Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4344-51. Epub 2006 Mar 14.

 

Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number.

Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME.  Science. 2006 Feb 17;311(5763):1008-12.

 

Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice.

Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Grant SG, Kind PC.  J Neurosci. 2006 Feb 1;26(5):1355-65.

 

Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones. 

Rockliffe N, Gawler D. FEBS Lett. 2006 Feb 6;580(3):831-8. Epub 2006 Jan 18.

 

Essential contribution of the ligand-binding beta B/beta C loop of PDZ1 and PDZ2 in the regulation of postsynaptic clustering, scaffolding, and localization of postsynaptic density-95. 

Nonaka M, Doi T, Fujiyoshi Y, Takemoto-Kimura S, Bito H.  J Neurosci. 2006 Jan 18;26(3):763-74.

 

2005

 

Differential expression of PSD proteins in age-related spatial learning impairments. 

Nyffeler M, Zhang WN, Feldon J, Knuesel I.  Neurobiol Aging. 2007 Jan;28(1):143-55. Epub 2005 Dec 28.

 

Light microscopic identification and immunocytochemical characterization of glutamatergic synapses in brain sections.

Melone M, Burette A, Weinberg RJ.  J Comp Neurol. 2005 Nov 28;492(4):495-509.

 

Differential roles of NR2A- and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. 

Kim MJ, Dunah AW, Wang YT, Sheng M.  Neuron. 2005 Jun 2;46(5):745-60.

 

Ontogeny of postsynaptic density proteins at glutamatergic synapses. 

Petralia RS, Sans N, Wang YX, Wenthold RJ.  Mol Cell Neurosci. 2005 Jul;29(3):436-52.

 

A role for synGAP in regulating neuronal apoptosis. 

Knuesel I, Elliott A, Chen HJ, Mansuy IM, Kennedy MB.  Eur J Neurosci. 2005 Feb;21(3):611-21.

 

Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development. 

Porter K, Komiyama NH, Vitalis T, Kind PC, Grant SG.  Eur J Neurosci. 2005 Jan;21(2):351-62.

 

2004

 

Impaired SynGAP expression and long-term spatial learning and memory in hippocampal CA1 area from rats previously exposed to perinatal hypoxia-induced insults: beneficial effects of A68930.

Yang SN, Huang CB, Yang CH, Lai MC, Chen WF, Wang CL, Wu CL, Huang LT.  Neurosci Lett. 2004 Nov 16;371(1):73-8.

 

SynGAP regulates spine formation. 

Vazquez LE, Chen HJ, Sokolova I, Knuesel I, Kennedy MB.  J Neurosci. 2004 Oct 6;24(40):8862-72.

 

Identification of novel phosphorylation sites on postsynaptic density proteins. 

Jaffe H, Vinade L, Dosemeci A.  Biochem Biophys Res Commun. 2004 Aug 13;321(1):210-8.

 

SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. 

Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE.  Neuron. 2004 Aug 19;43(4):563-74.

 

PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient brain ischemia in rat hippocampus. 

Song B, Yan XB, Zhang GY.

Brain Res. 2004 Apr 16;1005(1-2):44-50.

 

Role of Unc51.1 and its binding partners in CNS axon outgrowth. 

Tomoda T, Kim JH, Zhan C, Hatten ME.  Genes Dev. 2004 Mar 1;18(5):541-58. Epub 2004 Mar 10.

 

Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. 

Oh JS, Manzerra P, Kennedy MB.  J Biol Chem. 2004 Apr 23;279(17):17980-8. Epub 2004 Feb 17.

 

2003

 

Disruption of the NMDA receptor-PSD-95 interaction in hippocampal neurons with no obvious physiological short-term effect.

Lim IA, Merrill MA, Chen Y, Hell JW.  Neuropharmacology. 2003 Nov;45(6):738-54.

 

Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats.

Song B, Meng F, Yan X, Guo J, Zhang G.  Neurosci Lett. 2003 Oct 9;349(3):183-6.

 

Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity.

Hashimoto R, Fujimaki K, Jeong MR, Christ L, Chuang DM.  FEBS Lett. 2003 Mar 13;538(1-3):145-8.

 

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity.

Kim JH, Lee HK, Takamiya K, Huganir RL.  J Neurosci. 2003 Feb 15;23(4):1119-24.

 

2002

 

SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor.

Komiyama NH, Watabe AM, Carlisle HJ, Porter K, Charlesworth P, Monti J, Strathdee DJ, O’Carroll CM, Martin SJ, Morris RG, O’Dell TJ, Grant SG.  J Neurosci. 2002 Nov 15;22(22):9721-32.

 

2001

 

Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP.

Pei L, Teves RL, Wallace MC, Gurd JW.  J Cereb Blood Flow Metab. 2001 Aug;21(8):955-63.

 

Characterization of a novel synGAP isoform, synGAP-beta.

Li W, Okano A, Tian QB, Nakayama K, Furihata T, Nawa H, Suzuki T.  J Biol Chem. 2001 Jun 15;276(24):21417-24. Epub 2001 Feb 27.

 

2000

 

Physical mapping and evolution of the centromeric class I gene-containing region of the rat MHC. 

Walter L, Günther E.  Immunogenetics. 2000 Aug;51(10):829-37.

 

Anchoring proteins confer G protein sensitivity to an inward-rectifier K(+) channel through the GK domain.

Hibino H, Inanobe A, Tanemoto M, Fujita A, Doi K, Kubo T, Hata Y, Takai Y, Kurachi Y.  EMBO J. 2000 Jan 4;19(1):78-83.

 

Altered interaction between PSD-95 and the NMDA receptor following transient global ischemia.

Takagi N, Logan R, Teves L, Wallace MC, Gurd JW.  J Neurochem. 2000 Jan;74(1):169-78.

 

1999

 

Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS).

Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A.  Immunogenetics. 1999 Jul;49(7-8):644-52.

 

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus.

Zhang W, Vazquez L, Apperson M, Kennedy MB.  J Neurosci. 1999 Jan 1;19(1):96-108.

 

1998

 

A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II.

Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB.  Neuron. 1998 May;20(5):895-904. Erratum in: Neuron 2002 Jan 3;33(1):151.

 

SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family.

Kim JH, Liao D, Lau LF, Huganir RL.  Neuron. 1998 Apr;20(4):683-91.

 

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